Latest Herpes Cure Research

How do we advocate for a Herpes cure? Learn more about Herpes Cure Advocacy and how you can help.

Current Herpes Cure Pipeline


Herpes Cure Research: Published Studies

The following are published studies from investigators with work in the Herpes Cure Pipeline currently. To learn more about work prior to the Herpes Cure Pipeline, you can view prior studies in the NIH Reporter.

AiCurisA phase 2, multicenter, placebo-controlled study of single-dose squaric acid dibutyl ester to reduce frequency of outbreaks in patients with recurrent herpes labialis

Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes
2020




2016
Blue WillowIntranasal nanoemulsion-adjuvanted HSV-2 subunit vaccine is effective as a prophylactic and therapeutic vaccine using the guinea pig model of genital herpes2019

UPenn (Harvey Friedman) in partnership with
BioNtech
Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models

New vaccine prevents herpes in mice, guinea pigs
2021



2019
Excision BiotechnologyInhibition of HSV-1 Replication by Gene Editing Strategy2017
Fred Hutch Cancer CenterGene editing and elimination of latent herpes simplex virus in vivo2021
Rational VaccinesIntramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine

Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials
2020




2019
Redbiotech
SadbeA phase 2, multicenter, placebo-controlled study of single-dose squaric acid dibutyl ester to reduce frequency of outbreaks in patients with recurrent herpes labialis

Immune characteristics correlating with HSV-1 immune control and effect of squaric acid dibutyl ester on immune
characteristics of subjects with frequent herpes labialis episodes
2020




2018
Shanghai BDGeneIntracorneal delivery of HSV-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis2020
Thyreos VaccinesThe R2 non-neuroinvasive HSV-1 vaccine affords protection from genital HSV-2 infections in a guinea pig model

The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion
2020




2017
United BiopharmaClinical Study Link
X-Vax Model of vaccine efficacy against HSV-2 superinfection of HSV-1 seropositive mice demonstrates protection by antibodies mediating cellular cytotoxicity2020
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