How do we advocate for a Herpes cure? Learn more about Herpes Cure Advocacy and how you can help.

Current Herpes Cure Pipeline

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Herpes Cure Research: Published Studies

The following are published studies from investigators with work in the Herpes Cure Pipeline currently. To learn more about work prior to the Herpes Cure Pipeline, you can view prior studies in the NIH Reporter.

	AiCuris	A phase 2, multicenter, placebo-controlled study of single-dose squaric acid dibutyl ester to reduce frequency of outbreaks in patients with recurrent herpes labialis Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes	2020 2016
	Blue Willow	Intranasal nanoemulsion-adjuvanted HSV-2 subunit vaccine is effective as a prophylactic and therapeutic vaccine using the guinea pig model of genital herpes	2019
	UPenn (Harvey Friedman) in partnership with BioNtech	Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models New vaccine prevents herpes in mice, guinea pigs	2021 2019
	Excision Biotechnology	Inhibition of HSV-1 Replication by Gene Editing Strategy	2017
	Fred Hutch Cancer Center	Gene editing and elimination of latent herpes simplex virus in vivo	2021
	Rational Vaccines	Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials	2020 2019
	Redbiotech
	Sadbe	A phase 2, multicenter, placebo-controlled study of single-dose squaric acid dibutyl ester to reduce frequency of outbreaks in patients with recurrent herpes labialis Immune characteristics correlating with HSV-1 immune control and effect of squaric acid dibutyl ester on immune characteristics of subjects with frequent herpes labialis episodes	2020 2018
	Shanghai BDGene	Intracorneal delivery of HSV-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis	2020
	Thyreos Vaccines	The R2 non-neuroinvasive HSV-1 vaccine affords protection from genital HSV-2 infections in a guinea pig model The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion	2020 2017
	United Biopharma	Clinical Study Link
	X-Vax	Model of vaccine efficacy against HSV-2 superinfection of HSV-1 seropositive mice demonstrates protection by antibodies mediating cellular cytotoxicity	2020