Resources for Herpes Simplex Virus

World Health Organization	2020 WHO Study Global health sector strategy on Sexually Transmitted Infections, 2016-2021 Preferred Product Characteristics for Herpes Vaccine
National Academy of Science and Medicine	2021 Report Sexually Transmitted Infections: Adopting a Sexual Health Paradigm

Herpes Simplex Virus Research Overview

Dr. Anna Wald
Dr. Christine Johnston
Dr. David Koelle

National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU)
University of Bristol
Public Health England (PHE)

Prevalence Estimates Bulletin of the World Health Organization	Herpes simplex virus: global infection prevalence and incidence estimates, 2016
CDC Fact Sheet	https://www.cdc.gov/std/herpes/stdfact-herpes.htm
NCSD Data Brief	Prevalence of Herpes Simplex Virus Type 1 and Type 2 in Persons Aged 14–49: United States, 2015–2016

Sub Optimal Test Performance	Herpes simplex virus type 2 (HSV-2) IgG index values in two immunoassays in relation to HSV-2 IgG inhibition assay results
Sub Optimal Test Performance	Performance of Commercial Enzyme-Linked Immunoassays for Diagnosis of Herpes Simplex Virus-1 and Herpes Simplex Virus-2 Infection in a Clinical Setting
Sub Optimal Test Performance	Herpes simplex virus type 2 (HSV-2) Western blot confirmatory testing among men testing positive for HSV-2 using the focus enzyme-linked immunosorbent assay in a sexually transmitted disease clinic

(Recent and relevant projects to the Herpes treatment/cure pipeline to bringing a product to market.)

Fred Hutch Cancer Research Center	Gene editing and elimination of latent herpes simplex virus in vivo	2021
Aicuris (Pritelivir)	Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes	2016
SADBE Research	A phase 2, multicenter, placebo-controlled study of single-dose squaric acid dibutyl ester to reduce frequency of outbreaks in patients with recurrent herpes labialis Immune characteristics correlating with HSV-1 immune control and effect of squaric acid dibutyl ester on immune characteristics of subjects with frequent herpes labialis episodes	2020 2018
Harvey Friedman at UPenn	Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models New vaccine prevents herpes in mice, guinea pigs	2021 2019
Redbiotec	Model of vaccine efficacy against HSV-2 superinfection of HSV-1 seropositive mice demonstrates protection by antibodies mediating cellular cytotoxicity	2020

View the comprehensive Herpes Cure Advocacy Herpes Cure and Treatment pipeline here!

Help with advocacy at the FDA for accurate HSV diagnostic tests here!

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