Herpes Simplex Virus Potential Health Complications

Alzheimer’s Disease

How an increase in the copy number of HSV-1 during latency can cause Alzheimer’s disease: the viral and cellular dynamics according to the microcompetition model (2021)

A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease (2020)

Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease (2018)

Autoimmune Disease

Herpesviruses and autoimmunity (2008)

Bacterial Vaginosis

Risk of Bacterial Vaginosis Among Women With Herpes Simplex Virus Type 2 Infection: A Systematic Review and Meta-analysis (2015)

Incident Herpes Simplex Virus Type 2 Infection Increases the Risk of Subsequent Episodes of Bacterial Vaginosis (2013)

Bells Palsy

Herpes Simplex as Cause of Bell’s Palsy (1972)

Cognitive Decline

Infectious Burden and Cognitive Function (2013)

Encephalitis

Herpes Simplex Encephalitis (2021)

Herpesvirus infections of the central nervous system in immunocompromised patients (2012)

Herpes Simplex Encephalitis (2002)

Gastrointestinal

Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality (2016)

Mental Health, Depression and Anxiety

Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population (2019)

Psychological and psychosexual implications of herpes simplex virus infections (1996)

Neurological Complications

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis (2022)

OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection (2021)

Potential Connection Found between Neurodegenerative Diseases and HSV-1 (2021)

Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection (2020)

Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders (2019)

Neurological Complications of Herpes Simplex Virus Type 2 Infection (2008)

The expanding spectrum of herpesvirus infections of the nervous system (2001)

Nerve Damage

Postherpes Simplex Type 1 Neuralgia Simulating Postherpetic Neuralgia (1992)

Risk of HIV/AIDS

Association between bacterial vaginosis and Herpes simplex virus type‐2 infection: implications for HIV acquisition studies (2007)

Severe Disease

Disseminated Herpes Simplex Virus in an Immunocompetent Patient Without Presence of Epidermal or Mucosal Lesions (2021)

Two fatal herpesvirus cases: Treatable but easily missed diagnoses (2016)

Disseminated Primary Herpes Simplex Virus Type 2 Infection in a 22-Year-Old male (2015)

Fatal multiorgan failure associated with disseminated herpes simplex virus-1 infection: a case report. (2012)

Fatal disseminated herpes simplex virus infection in a previously healthy pregnant woman. A case report (2002)

Genital Herpes Simplex Virus (HSV) Infection (1998)

Other Herpesviruses

Epstein Barr Virus Linked to Cancer and Multiple Scleroris

Epstein Barr Virus Linked to Cancer and MS

EBV Link to Cancer and MS